I saw this poster at the AAPS a couple of years ago that showed how certain drugs based on their physicochemical profiles can get into the
blood brain barrier. It was then made into a full paper by a group in Germany. I just learned that the lead author Anna Petereit won the
Awarded in 2010 for the best paper by the European Journal of Pharmaceutics and Biopharmaceutics. Prediction of blood-brain barrier penetration of poorly soluble drug candidates using surface activity profiling.
(A.C. Petereit, J.B. Dressman et. al Eur J Pharm Biopharm. 2010 August;75(3):910-923). It is really a nice piece of work. In the materials and methods they used
Kibron's Delta-8 instrument to do a lot of the profiling.
I will talk about the blood brain barrier later..... (I should read the paper again).
