Thursday, 31 March 2011

Drugs into the Blood Brain Barrier???

I saw this poster at the AAPS a couple of years ago that showed how certain drugs based on their physicochemical profiles can get into the blood brain barrier.  It was then made into a full paper by a group in Germany.  I just learned that the lead author Anna Petereit won the Awarded in 2010 for the best paper by the European Journal of Pharmaceutics and Biopharmaceutics. Prediction of blood-brain barrier penetration of poorly soluble drug candidates using surface activity profiling.  (A.C. Petereit, J.B. Dressman et. al  Eur J Pharm Biopharm. 2010 August;75(3):910-923).  It is really a nice piece of work.  In the materials and methods they used Kibron's Delta-8 instrument to do a lot of the profiling. 
I will talk about the blood brain barrier later..... (I should read the paper again).