'Dyne With Me' explores surface tension of solutions used in everyday life. From inks to alcohol, drugs to dish soap, and everything in between....
Thursday, 31 March 2011
Drugs into the Blood Brain Barrier???
I saw this poster at the AAPS a couple of years ago that showed how certain drugs based on their physicochemical profiles can get into the blood brain barrier. It was then made into a full paper by a group in Germany. I just learned that the lead author Anna Petereit won the Awarded in 2010 for the best paper by the European Journal of Pharmaceutics and Biopharmaceutics. Prediction of blood-brain barrier penetration of poorly soluble drug candidates using surface activity profiling.(A.C. Petereit, J.B. Dressman et. al Eur J Pharm Biopharm. 2010 August;75(3):910-923). It is really a nice piece of work. In the materials and methods they used Kibron's Delta-8 instrument to do a lot of the profiling.
I will talk about the blood brain barrier later..... (I should read the paper again).